MECHANISMS FOR RTN - pF NEURON MODULATION 1 Ventrolateral Medullary Functional Connectivity and the 1 Respiratory and Central Chemoreceptor - Evoked Modulation of 2 Retrotrapezoid - Parafacial Neurons
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چکیده
Ventrolateral Medullary Functional Connectivity and the 1 Respiratory and Central Chemoreceptor-Evoked Modulation of 2 Retrotrapezoid-Parafacial Neurons 3 4 5 6 7 8 9 10 11 12 13 14 15 Mackenzie M. Ott, Sarah C. Nuding, Lauren S. Segers, Bruce G. Lindsey, and 16 Kendall F. Morris 17 18 Department of Molecular Pharmacology and Physiology and Neuroscience 19 Program, School of Biomedical Sciences, University of South Florida College of 20 Medicine, Tampa, Florida 33612 21 22 23 24 25 Running head: CIRCUIT MECHANISMS FOR RTN-pF NEURON MODULATION 26 27 28 29 30 31 32 33 Address correspondence to: 34 Dr. Kendall F. Morris 35 Department of Molecular Pharmacology and Physiology 36 School of Biomedical Sciences 37 University of South Florida College of Medicine 38 12901 Bruce B. Downs Blvd. 39 Tampa, Florida 33612-4799 40 41 Telephone: 813-974-1549 42 FAX: 813-974-3079 43 E-mail: [email protected] 44 45 Articles in PresS. J Neurophysiol (March 9, 2011). doi:10.1152/jn.00262.2010
منابع مشابه
Ventrolateral medullary functional connectivity and the respiratory and central chemoreceptor-evoked modulation of retrotrapezoid-parafacial neurons.
The medullary ventral respiratory column (VRC) of neurons is essential for respiratory motor pattern generation; however, the functional connections among these cells are not well understood. A rostral extension of the VRC, including the retrotrapezoid nucleus/parafacial region (RTN-pF), contains neurons responsive to local perturbations of CO(2)/pH. We addressed the hypothesis that both local ...
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Ventrolateral respiratory column (VRC) circuits that modulate breathing in response to changes in central chemoreceptor drive are incompletely understood. We employed multielectrode arrays and spike train correlation methods to test predictions of the hypothesis that pre-Bötzinger complex (pre-BötC) and retrotrapezoid nucleus/parafacial (RTN-pF) circuits cooperate in chemoreceptor-evoked tuning...
متن کاملCentral chemoreceptor modulation of breathing via multipath 1 tuning in medullary ventrolateral respiratory column circuits
44 Ventral respiratory column (VRC) circuits that modulate breathing in response to changes in 45 central chemoreceptor drive are incompletely understood. We employed multi-electrode arrays 46 and spike train correlation methods to test predictions of the hypothesis that pre-Bötzinger 47 complex (pre-BötC) and retrotrapezoid nucleus/parafacial (RTN-pF) circuits cooperate in 48 chemoreceptor-evo...
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Central mechanisms of coupling between respiratory and sympathetic systems are essential for the entrainment between the enhanced respiratory drive and sympathoexcitation in response to hypoxia. However, the brainstem nuclei and neuronal network involved in these respiratory-sympathetic interactions remain unclear. Here, we evaluated whether the increase in expiratory activity and expiratory-mo...
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The rat retrotrapezoid nucleus (RTN) contains neurons described as central chemoreceptors in the adult and respiratory rhythm-generating pacemakers in neonates [parafacial respiratory group (pfRG)]. Here we test the hypothesis that both RTN and pfRG neurons are intrinsically chemosensitive and tonically firing neurons whose respiratory rhythmicity is caused by a synaptic feedback from the centr...
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